Listening to this wonderful interview on the Hypermobility Happy Hour with Savita Sandhu, EDS dietitian, blew my mind: https://soundcloud.com/user-676536371/savita-sandhu-savvy-dietetics
In it, Savita talks about how histamine pulls up estrogen, which increases copper, which then suppresses zinc. So when she is working with anyone with EDS, she "first tackles nutrient deficiencies rather than eliminating foods." She explained that when mast cells release, a lot of histamine is released, which in turn drives zinc release. Zinc is important for stabilizing mast cells, and thus a lot of hypermobile people are zinc-deficient. She adds that an important thing to note when supplementing with Zinc is not to forget Copper, the ratio of which should be 1 to 1 ideally but some providers will want more like one zinc to 1.5 copper. This highlights the importance of working with a registered dietitian, as self-supplementation can lead to imbalances in other vitamins and minerals. Check out her amazing blog here: https://www.savvydietetics.com.au/blog Other deficiencies to pay attention to are Magnesium, B6, D3, C, B12, as well as Zinc. For more information on nutritional deficiencies, check out this video: https://www.youtube.com/watch?v=RpYmDvWp9KU
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